What Is The Role Of Antiproteases In Our Body?

A system of very important dense and carrier proteins within our body are called antiproteases. Recent reports have been described the function and mode of action of these protease inhibitor in our serum. The two most important antiprotease are called alpha -1 antitrypism (AAT) and alpha-2 macroglobulin (--2M). In addition to transport they maintain body's equilibrium between macromolecules and macroglobulins.

They main known function involving binding to proteases (enzymes) and to cytokines (cellular immune mediations). If we compare the enzymes to the solders, this antiprotease then represents amphibious armed personal carries. They enclose and carry the protease to their final destination, whether it would be for antitrypsin which reacts with trypsin and chemotrypsin, inactivating their enzyme activity. On the other hand the alpha -2 macroglobulin form an enzymaticaly active complex with the protease or with the cytokines, and together they became activated and react with the specific target such as the cells of the mononuclear phagocyte system (MPS).

According to the Adams, for example, high titers of free or inactive ---2M inhibit the endogenous protease and the tumor destroying capabilities of the MPS. Thus, it is thought that the binding to protease (such as the administered therapeutic enzymes) would have a beneficial effect by lowering the titers of the inactive and free –2M.

Add Comment

Report