Should U Give A Female Dog A Shot With A Big Needle When It Is Going 2 Have Puppies In 2 Months?

A big needle? Um, like a microchip? No, do not give a pregnant dog ANYTHING without consulting your vet. There is almost nothing that can be given that is safe unless it is absolutely necessary and only they can decide that and know the best course of action. You should probably go in for a visit and talk about the do's and dont's of caring for a pregnant dog (and whether you dog is more prone to risks or difficult births or infection instead of pregnancy and all that stuff)and what you are supposed to do from here. :-)

The size of the needle is irrelevant and will not cause harm to the puppies.  There is not need to use a needle larger than a 22 gauge needle when administering vaccines.  I would not give any vaccines to a pregnant dog at home; do not give vaccines purchased from a feed store or pet shop.  Ideally vaccines should not be given to a pregnant dog.  Vaccines should be given prior to breeding.  If it is determined specific circumstances exist that it would be in your dog's best interest to vaccinate than killed vaccines should be used.  All vaccines given to a pregnant dog should be done by a veterinarian.