In the year 1721, Lady Mary Wortley Montagu, who was the wife of the British ambassador to Turkey introduced vaccinations in England. She had her own children inoculated at Constantinople. Nonetheless there was a general fear that the very method could result in a severe or fatal attack of the disease that the vaccination is aiming to encumber.

The year 1798 witnessed the published work of Jenner, who gave the account of his experiments concerning his research on the development of vaccination in his book and eventually the practice of vaccination became recognized all over the world. Apart from the initial smallpox, the principle was developed for a number of other diseases like yellow fever, chicken pox, cholera, diphtheria, poliomyelitis (infantile paralysis) and typhoid. Children are more prone to all of these dangerous diseases, nevertheless the security provided by vaccination minimizes the risk of such perils to a great extent.