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Transubstantiation is the point at which the priest raises the unleavened bread (host) and the chalice during the Eucharist Prayer at the celebration of Holy Mass. Catholics believe that at this moment, the bread and wine transform into the actual Body and Blood of Jesus Christ. The Mass is a memorial of the Last Supper when Jesus gave his disciples bread and wine saying, "Take this all of you and eat it, this is my body which will be given up for you," and, "Take this all of you and drink from it, this is the cup of my blood, the blood of the new and everlasting covenant, it will be shed for you and for all for that sins may be forgiven. Do this in memory of me." This meal, on the eve of Christ's crucifixion, is know as the Institution of the Holy Eucharist, the first Mass. At every Mass since then, the Holy Spirit acts through the priest (who is in the person of Christ) and changes the bread and wine into the Body, Blood, Soul and Divinity of Jesus Christ Himself.
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