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After they are vaccinated and spay or neutered. You want to protect them and prevent more "unwanted" animals as well.
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You should let your cat out once hes/shes neutered or it might stay to the nest where his/hers spawns are.Also when there about 2 years old that should be the proper time to let your cat out make sure you never declaw your cats hands they will need it for protection against prey/enemies
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