Considering that both Charlotte and Winston-Salem are in the American state of North Carolina the distance is not very great. The distance in miles between Charlotte and Winston-Salem is 79.1 miles. If you're planning to drive from one to the other your travelling time is approximately and hour and a half, more precisely one hour and 23 minutes under normal traffic conditions. Keep in mind that you will have to head north west on the E Trade Street towards the North Davidson Street and then turn right at N Caldwell Street.
North Carolina was one of the 'Thirteen' colonies of the United States. History enthusiasts will be interested to note that it was the home of the first English colony of the Americas. It was also the place where the famous Wright brothers made their first heavier-than-air flight in 1903 near Kitty Hawk. Its population is 8,856,505 as per the findings of a 2006 census. North Carolina has a varied climate- in fact it has the greatest variation in climate amongst all the south-eastern states.