How To Design A Game In VB ?

You have to draw the pictures for each possible orientation of objects, that's the easy way, (for the beginning). Or you have to render the images at that time, (little bit hard).
You can use the picture box to hold a graphic on a form. And load an image to a picture box using LoadImage method. then you can move it by changing the Left and Top properties. You can take the Keyboard Key presses through the forms KeyDown event.
Use a Timer for repeating functions that constantly moves the picture boxes. When you write a method inside a timer it will be executed again and again with a given time interval.