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I usually cook a bread pan size meatloaf 45-60 minutes. Two pounds sounds like maybe 1/2 of a bread pan so maybe 30-40 minutes. I usually cut off an end slice to make sure the meat is cooked.
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I bake a 2 lb. Meatloaf for at least 1 hour. If you want the outside to be a little crusty, (and I do), I bake it at 425 or 450 degrees.
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