It means that a person is coming down off of drugs such as cocaine heroin methamphetamine etc.
It all starts with the shakes then comes the bathroom stages, constantly going and it just doesn't seem to end. After this is the restlessness n irritibility. If you make it the three days you're on the road you want to be on.
There have been slaves for thousands of years, they helped build the pyramids. Babylon took jews into slavery, the Bible tells about it. Generally the conditions were less than favorable.
Jeez! Try to pick up a book.