I would assume that if someone is depressed/ high anxiety they would probably not eat good (to much or lack of ) and when a person doesn't eat correctly they will either gain lots of weight and become obese or they stop eating and become malnourished and body starts feeding off it's self.
When a person doesn't eat correctly their appearance can change. Unhealthy eating can make a person seem to be aged older and possibly make teeth yucky and fall out. When the body is malnourished energy drops so a person will be sluggish and sleep more ( or eat more) and become more depressed. Also these things can cause someone to have a really bad attitude and that can make someone ugly...I hope this helps. I'm not an expert so this is just my assumption.