Bennie George
Bennie George answered

Gene synthesis is the process of chemically synthesizing double-stranded DNA molecules in vitro. It differs from molecular cloning and polymerase chain reaction (PCR) in that the researchers do not have to begin with preexisting DNA sequences. Therefore, it is possible to make a completely synthetic double-stranded DNA molecule with no apparent limits … Read more

Bennie George
Bennie George answered

Mammalian cells offer advantages in post-translational modification and protein folding that are crucial in the production of eukaryotic proteins such as antibodies, recombinant proteins etc. Stable cell lines overexpressing specific proteins have integrated GOI in the genome and are costly and vital assets for life science research.

Bennie George
Bennie George answered

Virus packaging is a kind of biological technology, which is developed from the characteristics of virus replication. In this technology, virus packages the target gene into the structural and non structural proteins to produce viruses which have certain infectivity but have no pathogenicity.

Bennie George
Bennie George answered

Oncology is a branch of medicine that deals with the prevention, diagnosis and treatment of cancer. Research contains mechanism study (including molecule mechanism), pathological research, surgical method, medical treatment therapy (chemotherapy, radiotherapy), management for an individual patient, new drug development, etc. Obviously, oncology is often managed through discussion on multi-disciplinary.

Bennie George
Bennie George answered

Adult stem cells are undifferentiated cells, found throughout the body after development that multiply by cell division to replenish dying cells and regenerate damaged tissues. Also known as somatic stem cells, they can be found in juvenile as well as adult animals and human bodies. Creative Bioarray provides adult stem cells from … Read more

Bennie George
Bennie George answered

ICH S7B guideline1 regulates in vitro IKr assay (such as hERG safety assay) and in vitro QT assay for identifying and assessing the potential of a test compound to delay ventricular repolarization. Ventricular repolarization is a complex physiological process determined by the duration of the cardiac action potential. It is the net … Read more

Bennie George
Bennie George answered

Creative Bioarray maintains various human and animal tumor cell lines that are invaluable for medical, scientific and pharmaceutical institutions. Creative Bioarray consistently attains the highest standards and uses the most reliable procedures to verify every cell line.

Every study is different and requires different cells and samples. Creative Bioarray has the largest selection … Read more

Bennie George
Bennie George answered

The nervous system is responsible for sending, receiving and interpreting signals from all over the body and coordinates its action. It processes and intergrates information on a variety of levels, and directs the body to respond appropriately. The nervous cell system consists of neurons, endothelial cells, pericytes, smooth muscle cells, fibroblasts, Schwann … Read more

Bennie George
Bennie George answered

Gene variant library is a systematic combination of a large number of variant (mutant) DNA sequences. It is increasingly used in a wide range of research areas, such as high-throughput screening for drug discovery, directed evolution for protein engineering, and creating  high diversity synthetic antibody library for screening antibody variants with high … Read more

Bennie George
Bennie George answered

High-throughput ion channel binding assays have been configured for filter binding assays, scintillation proximity assays, and fluorescence polarization assays. Ligand binding assays can detect compounds that compete with ligands for binding to a specific site. Given its low cost and high throughput, binding assays have been developed for many voltage-gated and ligand-gated … Read more

Bennie George
Bennie George answered

Bromodomains, as the "readers" of histone code, are responsible in transducing the signal carried by acetylated lysine residues and translating it into various normal or abnormal phenotypes. With the development of small molecule bromodomain inhibitors, the role of bromodomains in translating a deregulated cell acetylome into disease phenotypes was recently unveiled.

Bennie George
Bennie George answered

Protein phosphorylation is vital for normal cellular function and a major control mechanism of a wide range of physiological processes. Phosphate groups are post-translational modifications that regulate many disease states, including cancers, neurological diseases, diabetes, pain, autoimmune disorders, and cardiovascular diseases.

Bennie George
Bennie George answered

Transporters are a kind of membrane proteins controlling uptake and efflux of essential nutrients ions, neurotransmitters, cellular waste, environmental toxins, and drugs, into and out of cells and organelles. Therefore, transporters play a significant important role in drug's clinical efficacy and safety. Currently, transporters are used as therapeutic targets to treat numerous … Read more

Bennie George
Bennie George answered

Baculovirus-Insect cell expression system is one of the most popular eukaryotic expression systems for research and industrial applications. There are several advantages of using the baculovirus-Insect cell expression system, such as improved solubility, ability to incorporate post-translational modifications, and higher yield of secreted proteins. Baculovirus-Insect cell expression system is widely used to … Read more

Bennie George
Bennie George answered

Kinases are a large family contains 518 members which represent one of the most important and largest superfamilies of drugable targets and a major research field for both the pharmaceutical industry and academic research. Kinase signaling pathways play such a primary role in regulating cell proliferation, metabolism, and death, which indicate that … Read more

Bennie George
Bennie George answered

Virus packaging is a kind of biological technology, which is developed from the characteristics of virus replication. In this technology, virus packages the target gene into the structural and non structural proteins to produce viruses which have certain infectivity but have no pathogenicity. It is usually used for gene expression, gene silencing, … Read more

Bennie George
Bennie George answered

Endothelial cells play multiple physiological functions and are central to many pathological processes. The liver contains two distinct endothelial cell types: Vascular and sinusoidal. Sinusoidal endothelial cells (SEC) are microvascular endothelial cells with a unique phenotype reminiscent of dendritic cells and a unique function as antigen-presenting cells for CD4+ T cells.

Bennie George
Bennie George answered

The human genome is full of repeated DNA sequences which come in various sizes and are classified according to the length of the core repeat units, the number of contiguous repeat units, and/or the overall length of the repeat region. DNA regions with short repeat units (usually 2-6 bp in length) are called Short Tandem … Read more